Reply to Wittkowski and Liu (Beyond the TDT: Rejoinder to Ewens and Spielman)
نویسندگان
چکیده
61 6 Sham PC, Zhao JH, Waldman I, Curtis D: Should ambiguous trios for the TDT be discarded? Ann Hum Genet 2000;64:575–576. 7 Aidoo M, Terlouw DJ, Kolczak MS, et al: Protective effects of the sickle cell gene against malaria morbidity and mortality. Lancet 2002;359(9314): 1311–1312. 8 Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993;52(3):506–516. 9 Laird NM, Blacker D, Wilcox M: The sib transmission/disequilibrium test is a Mantel-Haenszel test [letter]. Am J Hum Genet 1998;52(3):506–516.
منابع مشابه
Beyond the TDT: Rejoinder to Ewens and Spielman
1 Wittkowski KM, Liu X: A statistically valid alternative to the TDT. Hum Hered 2002;54:157–164. 2 Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993;52(3):506–516. 3 Sham PC, Zhao JH, Waldman I, Curtis, D: Should ambiguous trios for the TDT be discarded? Ann Hum Genet 2000...
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In linkage analysis for mapping genetic diseases, the transmission/disequilibrium test TDT uses the linkage disequilibrium LD between some marker and trait loci for precise genetic mapping while avoiding confounding due to population stratification. The sib-TDT S-TDT and combinedTDT C-TDT proposed by Spielman and Ewens can combine data from families with and without parental marker genotypes PM...
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The transmission disequilibrium test (TDT) is a useful method to locate mutations linked to disease genes associated with complex diseases. TDT requires genotypes of affected individuals and their parents. Recently, Ewens and Spielman (Am J Hum Genet 1998;62:450-8) extended the TDT for use in sibships with at least one affected and one unaffected individual and devised a new test called the sib...
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